Core Outcome Set for Depression

To change outcomes for patients, we need to know what we should measure in studies evaluating the harms and benefits of treatment. In other words, what does “efficacy” really mean when it comes to depression treatment? This meaning can also change when the treatment varies, for example drugs, psychotherapy, neurostimulation, and psychosocial intervention.
A Core Outcome Set is a set of outcomes to be included in all trials of a given condition to improve the comparison and combination of their results in evidence synthesis. To learn more about COS.
This program has received initial funding by the Fondation Recherche Médicale (FRM 2017-2020) and has received a funding by the Fondation de France to be terminated (2024-2027)


  • Veal C., Tomlinson A., Cipriani A., Bulteau S., Henry C., Muh C., Touboul S., De Waal N., Levy-Soussan H., Furukawa T-A, Fried E.I, Tran V-T., Chevance A., Heterogeneity of outcome measures in depression trials and the relevance of outcome measures content to patients: a systematic review, The Lancet Psychiatry, 2024 10.1016/S2215-0366(23)00438-8 (summarized in this blog post by Eiko Fried PhD)
  • Chevance A., Tomlinson A., Ravaud P., Touboul S., Henshall C., Tran V-T, Cipriani A., Important Important adverse events to be evaluated in antidepressant trials and meta-analysis: a large international preference study, Evid Based Ment Health. 2022 Dec;25(e1):e41-e48 DOI: 10.1136/ebmental-2021-300418
  • Chevance A., Ravaud P., Tomlinson A., Le Berre C., Teufer B., Touboul S., Fried E., Gartlehner G., Cipriani A., Tran V-T., Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey, The Lancet Psychiatry, 2020; 7(8):692-702. DOI: 10.1016/S2215-0366(20)30191-7 (summarized in this blog post by Eiko Fried, PhD)
  • Chevance A, Tran V-T, Ravaud P. Controversy and Debate Series on Core Outcome Sets. Paper 1: Improving the generalizability and credibility of core outcome sets (COS) by a large and international participation of diverse stakeholders. J Clin Epidemiol. 2020; 125:206-212.e1. DOI: 10.1016/j.jclinepi.2020.01.004
  • Chevance A, Tran V-T, Ravaud P. Controversy and Debate Series on Core Outcome Sets. Paper 7: Response to comments on the paper 2-6 re « Improving the generalizability and credibility of Core Outcome Sets (COSs) by involving large international sample of participants ». J Clin Epidemiol. 2020;125:232-4. DOI: 10.1016/j.jclinepi.2020.06.019

Mental pain – multidisciplinary evidence synthesis

Whilst looking for outcomes that matter to patients, a study I conducted on 3003 people with experience of depression, their close-ones and clinicians, I discovered that mental pain was the third most cited outcome. However, despite its relevance to patients, none of the most commonly used scales for depression measure mental pain.
This fact became the starting point of a multidisciplinary evidence synthesis programme gathering multidisciplinary knowledge on mental pain. This program is supported by the Fondation Bettencourt Schueller. Ongoing projects involve contributions of Baptiste Brossard (Assistant professor in Sociology – York University), Samy Kozlowitz, Charlotte Geindre, Luz Ascarate, Etienne Duranté.


  • Charvet C., Boutron I., Morvan Y., Le Berre C., Touboul S., Gaillard R., Fried E., Chevance A., How to measure mental pain: a systematic review assessing measures of mental pain, Evid Based Ment Health. 2022 Nov;25(4):e4. DOI: 10.1136/ebmental-2021-300350

ComPaRe Depression is a French-speaking e-cohort of people with mood disorders. The monthly collection of self-reported real-life data allows for the exploration of cognitive, psychological, sociological, cultural, clinical and epidemiological characteristics for mood disorders. Long-term follow-ups within the ComPaRe Depression cohort will allow us to uncover determinants of mood disorder trajectories and help develop healthcare and medico-social interventions to address the needs of people with mood disorders.

The recruitment in ComPaRe Dépression started on November the 24th 2023. In June 2024, up to 4100 participants were included.

ComPare Depression is nested in the largest ComPaRe platform involving nearly 50,000 participants. ComPaRe follows the FAIR principles (Findable, Accessible, Interoperable, Reusable) and is open to any researcher/research project with public funding.

ComPaRe Depression is led by a multidisciplinary scientific committee including researchers (epidemiology and sociology), medical doctors (psychiatrists and general practitioners) and experts with lived-experience.